Installed Windows 3.11 along with the Orpheus Win 3.1x drivers, CD Audio and the modified SVGA driver (to enable 256 colors).
I also installed and ran Civilization II which did work, at least initially.
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Unfortunately I ran into an issue where I lost digital audio playback a couple of times. One of these instances happened after initially installing the CD audio driver.
This had a side effect of seemingly breaking the Orpheus II's Sound Blaster compatibility. Even booting into DOS and trying digital audio would now fail to play back correctly.
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I could get everything working again by physically removing the card and re-installing it. But I'm not entirely sure what is going on and why it stopped working.
I've added some CPU throttling by setting a lower multiplier (x14 instead of x17), and disabling L1 cache before loading Win 3.11. This way I can at least see if it's a speed dependency issue.
On a potentially related note, I also lost audio playback with the Audigy 2 ZS under Windows XP.
This was particularly weird since it didn't report any issues with the hardware. Playback device and mixer volumes seemed fine. I even ran the Creative Labs diagnostics and it reported everything was fine. I could even try playing audio and it would act like audio was playing, just produce no sound.
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Thinking I should re-install the drivers, I inserted the Creative Labs Audigy 2 ZS setup CD. Upon loading the splash screen, it suddenly started playing audio again. Quitting the setup program and audio was once again working in Windows XP.
I have no idea what this issue was.