For any ISA card you'd need an external ISA adapter. The soundcards you mention are 16 Bit ISA slot cards, someone on this thread has made a 16 Bit ISA adapter (many soundcards need a -ve supply that the pocket386 doesnt supply, so you need to provide -5V or -12V depending on the card....), but I dont think there is a commercially available one. If you go for the 8Bit ISA adapter (ISA8-EXP-01 ) you 'may' be able to get them to work - some 16 bit cards will work in 8 bit slots with some settings, there are threads on Vogons on this...
But to be 100% sure it will work its safer to stick with cards like the original soundblaster 1, 1.5 or 2 - or clones... which only offer 8 Bit mono sound. The adapters are just bare PCBs, for everday use you really need an enclosure or at least some sort of support to protect/enclose/hold the cards, there are a few 3D printable models out there...
Ive not used QEMU, but I can say 86Box works great for installing operating systems (with the caveat that I had issues with compatibility of the virtual hard drive files and some image writing software). You just set up a virtual machine thats a close match for the Pocket 386, but add in a floppy drive or CDROM drive - whatever format your OS install disk images are on and your away...
I had issues if I selected zero wait states for the memory type, other than that it was pretty painless.
Its wise to set up a virtual hard drive with cyl/sector etc geometry that matches your compact flash card (put it in the pocket 386 and look in the BIOS hard drive autodetect, or if your quick catch it on boot), its easier to write the image then. I then use BalenaEtcher (free, use the uncompressed hard drive image type in 86Box for compatibility) to copy the hard disk 86Box image to the compact flash.
Ive done dos 6.22+ win 3.11, an early pre ie4 version of win95 (I think the early ones are faster?) & RedHat 5.2 (really, dont, just dont, its so slowwwwww) like this, on a variety of different size/types of compact flash. I havent done freedos, but I cant see why it wouldnt work, so long as you have the install disk image files (.iso)