Based on everything you've said, I would recommend pairing the PicoGUS with the Audician 32. This is the exact combo I use the most in my pure DOS system, for maximum flexibility and compatibility.
For gaming, my Audician has been trouble-free for external MIDI devices (3 Roland Sound Canvas + 1 Yamaha) but you can always use the PicoGUS in MPU401 mode instead. Audician as SB-Pro for sound effects, in 8-bit stereo.
My PicoGUS usually stays in GUS mode, and gets used primarily for demoscene and music trackers/players. I do use it with a handful of games with tracker-based music (Epic Pinball, Pinball Fantasies, One Must Fall 2097) where its quality is vastly better than any SB card.
I have/use several Creative cards, including a SB32 CT3600 that I purchased new in the mid-90's. While I have a soft spot for that card, it (and the other 16/32/AWE32 PNP cards) can be such a pain - PnP issues, AWEUTIL memory usage, DSP w/ MIDI bugs, and SB-Pro digital audio works but in mono. Yes, I'm aware of Unisound and DSP upgrade, but that is too much work, and that's coming from someone who hand-soldered a PicoGUS v1.1.1 board.
sydres wrote on 2026-01-22, 14:31:
... For sure the resource allocation will be interesting and possibly limiting but I like options which is why I have two Roland and two Yamaha sound modules. ...
Indeed - this is why I do not recommend the CT3600 or CT3670 in a multi-card system. Even as a single sound card, that IDE CD-ROM PnP config has been buggy and likes to cause resource conflicts with dual-IDE motherboards, at least for me.
If you prefer real OPL for FM, and also have external MIDI devices (which are better match for most games than native AWE32 EMU8000) the SB 32's don't really offer you much else. The only thing you're technically missing is support for 16-bit digital audio in SB16 mode. The Audician will do 16-bit in WSS mode, which I have confirmed in DOS (Cubicplayer v1.6 - I don't recall if any DOS games support WSS) but honestly that is one of the few quality differences I don't notice in games.
In other words, skip any Creative PnP card, and use that time to enjoy those DOS games.