While testing a handful of emulators on my "new" Windows NT 4.0 PC, I discovered that KGen98 was actually usable. It's a DOS program, so I didn't expect much from it on NT - however, I successfully played through a significant chunk of Sonic 3 & Knuckles with it.
The included "readme" file states that a real Sound Blaster is required, and indeed, I have yet to get this emulator working with SBEMU or VSBHDA. Luckily, VDMSound can coax it into producing audio. The last release of it to support Windows NT 4.0 is 2.0.4, which can be downloaded from the SourceForge repository.
Once VDMSound is installed, the only issues I encounter are a fair amount of input lag and a half-second delay in the generated audio. These quirks are most likely the result of running this program in the NTVDM; I didn't experience them on DOS. Either way, this emulator works well enough to handle the short bursts of Sonic I play from time to time.

edit:
off-topic content removed as it will only serve to complicate things further
remember that you can always message/report any issues or grievances to the moderation team , thank you!

I know you can run DOSBox 0.65 on Windows NT 3.51, so it should work on NT 4.0 too. Fun fact: NT 3.51 also plays nice with Unreal 1 engine games.