It looks like many combined problems.
Mouse works properly in dos on Pentium III 450, p166+, 486dx40 and in windows xp.
Sound/music works properly in Windows XP.
Music in dos, everybody can reproduce it: after starting the game when you can turn around, after 2,5 minutes the music got hick up for 20 seconds, and again later before the end of song. This was my only problem. It doesn't affect talking. It happens on real PCs too. in both English and polish versions patched and unpatched. I also remember it from the past - i thought that was caused by my cd being scratched. 😉
I guess Jusko may also have some problems with using too many cycles for his cpu to handle, and more probably some linux sdl problems.
Jusko can you try prebuffer=50 ?
rate=44100
blocksize=4096
core=dynamic
cycles=30000
(and of course music won't be help at those broken moments 😉 )