Ok, I have a couple more tests to add.  I tried the Gateworld games (1 and 2.)  Of course, Adlib works without issue, but when I try MT32 emulation, it doesn't work.  Possibly this game is one of those that use some of the more advanced things that VDMSound can't emulate, but if so, then that wouldn't explain what happened with GW2.  In GW2, if I tried IRQ2, I got no music and no mouse.  If I tried IRQ 9 the keyboard and mouse both wouldn't work and I still got no sound.  When I tried IRQ 7 the game ran fine, and the keyboard and mouse worked, but, still no music.  I tried both with SB emulation on and off, but with MIDI emulation on in each test.
When I tried GW1, when I tried IRQs 2 & 7 it told me that it couldn't find the MT32 hardware (yes, I set up the drivers properly) and when I tried IRQ9 it appeared to have completly locked up.  The LED didn't blink, so I doubt it was sending sysex data or anything like that either.  I waited a pretty good while on the thing, but, eventually had to give up.
(These games can be found on the-underdogs website if anyone wants to test VDMSound with them themselves.)
EDIT:  Oh, and I'm sorry, I forgot I should have followed those posting guidelines.  Perhaps some of the info will help:
-CPU:  AMD Athlon 1.4GHz (TB, not XP)
-Motherboard:  MSI K7T133, which seems to actually be pretty darned good.
-Sound card:  Actually, two.  Yamaha YXG744 (give or take a few 10s) and a Sound Blaster Live!  I set the default device for digital audio to the Yamaha since SBLive's digital audio sucks (no, let's not get into a battle over this please,) and I set the MIDI to the SBLive for the soundfonts.
Memory:  I installed XP when I had 256, now I have 512.  I know that Win9x never properly took advantage of more memory when you upgraded, but perhaps XP doesn't have that problem.  I can't really be sure since I had enough ram to get the same basic performance before, so it's not like upgrading from, say, 64 to 256.
-Video card:  Gainward Ultra/650XP Golden Sample (a Geforce 4 Ti-4200 with 128MB of ram, vivo, and DVI)
-Video mode:  actually, it didn't occur to me at the time that it could be an issue.  I told the games to use SVGA rather than VGA, and things seemed fine.  As soon as I get a chance, I'll try them in VGA and see if it affects things.
-Operating system:  Windows XP Proffessional (corporate version.)
-Reproduction of the problem:  it happens every time I've tried it, which is quite a few.