(I don't see how a lot of this is relevant, but hey, I read the sticky and nobody does that.)
MOBO: Gigabyte Z68MA-D2H-B3 v1.0
CPU: Intel i5-2400 (3.2 GHz x4)
RAM: 4 GB DDR3
GPU: Nvidia Geforce GTX 560 (1 GB)
Sound: Realtek High Definition Audio (Onboard)
OS: Windows 7 Ultimate 64-bit
Mouse: Razer Deathadder 3.5G

Game: Radix: Beyond the Void 2.0

Problem: I can play Radix perfectly fine for about 20 minutes, at which point the game will abruptly stop reading my mouse's X-Axis input. I can still turn with the arrow keys, and the Y-Axis is read perfectly fine.

Reproduce: Always. It occurs roughly 20 minutes after launching the program.

Sound Mode: Soundblaster 16, default settings, stereo

Video Mode: Unsure. I'm assuming Direct3D. It's set to "overlay" in D-Fend Reloaded, 0x0 resolution, vesa_oldvbe

Emulator: DOSBox 0.74, D-Fend Reloaded 1.3.4

Attempted steps: Aside from simple things like quitting to menu and reloading, not much as I don't know what's to change. As it so happens, as I was writing this, I just so happened to have System Information for Windows open and found that I neglected to install the proper drivers for my mouse. After restarting and double-checking that my drivers were fine, I tried Radix again. I had the problem once more.