I've had the following issues:

1. Frequent crashes while playing Gargantuan - usually the 'crash' is that the game freezes during the computer move. I always play Blue and play the long game.
2. A saved game gets lost after I close the game. I can save a restore a game while playing, but if I try to restore the game after I've closed the program, it's not there.

Problems seen with DOSBox version 0.74. OS Windows XP and Vista.