Greetings, after countless hours of trying to get one really old particular game running, I finally managed to fix it. The game is an ancient Icelandic game developed back in 1994 called "Sægreifinn" or "The Sea Baron" a fish industry simulator developed in North of Iceland. However when running it in DosBox you were bound to a maximum frame of 0-639 horizontal space and 0-199 in vertical space, and the vertical space is exactly what is needed to be able to navigate in the game.

This problem is caused by Windows standard way of emulating the mouse in MS-DOS and the problem resides within WinNT/2000/XP etc (int 33h, functions 3, 5 and 6) and the popular MOUSE2KV fix did not seem to fix anything.

After reading and searching both on these forums (which was really helpful) I could read that some people were having problems with games, some of them fixed and some of them not. But they all seem to have something to do with mouse compatibility.

I don't know if I'm breaking any "forum rules" or code, but after trying 20 different mousedrivers (including CuteMouse) and all the DosBox configuration tricks possible I stumbled upon a old mouse driver which seems to somehow bypass, or alter the INT 33h function.

The Driver is available at http://www.mdgx.com/drv.htm and is called "Alps GlidePoint (AMOUSE.COM) 9.10 16-bit DOS Mouse Driver TSR"
This particular driver seems to support a wide variety of mice and in my case, completely fixed the mouse issue within the game. Simply putting the AMOUSE.EXE into the game directory did the trick.

So instead of running the GAME.EXE straight, I point DosBox to run a simple .bat file instead:

>> Bat file begins
AMOUSE
GAME.EXE
<< Bat file ends

Have a good day!