Descent 2 doesn't work too well with the default dosbox configuration for some reason. It tries to change from some resolution to other with fullresolution=original, and will just display a blank screen - with music running - in this native 1366x768 monitor until you alt+enter wait for the render and alt+enter again. This can be avoided by overriding fullresolution=600x480 though i suspect this may interfere with the ingame max resolution, which is suposed to be 800x600. Although it only seems to affect the ingame screen not the whole window, so maybe not.

Well, i have a solution, but i was wondering if someone else experienced this? I know about the source ports etc but i'm just curious that such a popular game won't run on the default dosbox hardware.