I keep going back to that thread whenever I am working on a 386 or 486 build... But so many notable titles are missing. It's not perfect, but includes big titles were left out:
1991
Battle Chess Enhanced
Jones in the Fast Lane
EcoQuest: The Search for Cetus
Mixed‑Up Mother Goose Deluxe
Sherlock Holmes: Consulting Detective
Stellar 7: Draxon’s Revenge
1992
The Adventures of Willy Beamish
Dune
King's Quest V
LOOM
The Manhole
The Secret of Monkey Island
Space Quest IV
Wing Commander II: Vengeance of the Kilrathi Deluxe Edition
1993
The 7th Guest
Blue Force
Command Adventures: Starship
Day of the Tentacle
Dragon's Lair
Gadget: Invention, Travel, & Adventure
Gateway II: Homeworld
The Journeyman Project
JRR Tolkiens Lord of the Rings Vol 1
Inca
Indiana Jones and the Fate of Atlantis
King's Quest VI
The Legend of Kyrandia: Book One - Fables and Fiends
Laura Bow II: The Dagger of Amon Ra
Maniac Mansion: Day of the Tentacle
Mad Dog McCree
MegaRace
Metal & Lace
Myst
Police Quest 4
Rebel Assault
Return to Zork
Sam & Max Hit the Road
Star Trek: 25th Anniversary
Ultima Underworld 1 + 2
1994
Creature Shock
Flash Traffic
The Incredible Machine 2
Knights of Xentar
King's Quest 7
Leisure Suit Larry 6: Shape Up or Slip Out!
Might & Magic: The World of Xeen
Might & Magic: World of Xeen
Police Quest: Open Season
Pirates! Gold
Simon the Sorcerer
Under a Killing Moon
Wing Commander I (speech pack)
Wing Commander III
Wing Commander Privateer
P3 866, V3, SB Audigy2
P2 400, TNT, V2, SB Audigy2 ZS
P233 MMX, Mystique220, V1, AWE64
P166, S3 Virge, SB32, PicoGus
486DX4 100, CLGD5424, SB32
Prolinea 4/50, ET4000, SB16
SC386SX 25, TVGA8900D, Audician32
286 10, ATI VGA, Forte16
PS2 30/286, SBP