My main DOS rig is a multi sound card build:
1- Ensoniq Soundscape -> P:350h I:15 D:0;
2- Orpheus II includes:
SB Pro P:220h I:5 D:1 MPU:320h (Turtle Beach Rio);
GUS (Interwave) : P:260h I:7 D:7 (can emulate MPU at port 300)
Intelligent Mode MPU: 330h
3- Adlib Gold / Goldlib clone -> P:398h I:3 D:3;
4- Pro Audio Spectrum (Dual OPL2) -> P:388h I:6 D:2
5- Sound Blaster AWE64 Gold (for EMU8000 synth only) -> P:240h I:Disabled D:Disabled EMU8000 at port 640;
(MPU and AWEUTIL emulation via port 300h)
6- IBM Music Feature card -> P:2A40h
7- PicoMEM for -> CMS/Game Blaster P:210h, Tandy 3 Voice P:1E0h , Mindscape MB P:2F0h
8- Roland RAP-10 -> P:340h I:11 D:5
9- Covox Speech Thing on Parallel Port
I'm using a special PC case for this and added a 2 slot backplane to expand the ISA bus. Only the Sound Blaster part on the AWE 64 Gold needs to be disabled, but i can just as easily disable the Crystal chip on the Orhpeus II and use the SB16 part on the AWE64.
Question is could i add anymore soundcards? Amazingly the answer is yes, probably an Aria based chipset card would be a good option, or a Turtle Beach Multisound Classic i still have IRQ 10 which i can use for the Aria or a Multisound, with DMA 6 being suitable for the native portion of the Aria also. The Multisound would require a 32kb window for SMA (instead of DMA) in the upper memory area which i also could spare.
The Aria is the most practical option having support for most important sound libraries (AIL2, AIL/32, DIGPAK, HMI SOS) (no MSS3 sadly). The Multisound Classic is only supported through DIGPAK/MIDPAK, with the music driver apparently not working so well, which is a shame considering the EMU/Proteus synth it includes is actually very nice. The Multisound Classic was released around the same time as the LAPC-I but unfortunately native support for its synth is extremely limited.
This is of course an exercise in excess, but fun nevertheless. I aimed to prove that if you plan well your resources you can have several sound cards with no conflicts. Some times i go: "With which Sound Card will i play this game today?"