I have always been curious about this awesome feature, and finally wanted to give it a try with my Logitech M-35 as secondary serial mouse.
It didn't work. So I started to suspect my mouse was neither Mouse Systems nor Microsoft compatible (the two protocols the game supports) and built a simple program to find out.
Well, turned out - bollocks; it is a normal MS mouse (with middle button extension) and game code was to blame.
I have patched the "OEM version" with EXE labeled 1997 that I got on a reissue CD from 2000s to initialize the UART more reasonably and the game works on a Core Quad.

The patch is on the same github project page in the release section.

The test programs needs Watcom so not sharing .EXE as I want source code to be GPL 2, but it's as easy as single WCL run to build.