Some updates on my end with my P8B75-M. Had to take out that board for some repair work as I noticed 5 bulged caps on it, though the board itself doesn't exhibit any anomaly when using in this state.
These bulged caps (6.3V/820uF), which were near USB ports and headers, all belonged to the +5V_USB_PS2 rail according to the boardview. Apparently that rail had footprints for 6 capacitors with one optional and unpopulated, so this means all caps on that rail have failed for whatever reasons before I got it. I've replaced the bulged caps with polymers of the same spec but smaller in size, as well as actually populating the one that were optional before (so 6 in total). Powered on the board again and everything seems to be good so far.
I tested with a non-PnP Sound Blaster 16 (CT2290) and it can be correctly picked up by UNISOUND. The card in overall behaves very similar to the PnP CT2950 that I'm currently running on my X99 system.
However, the card apparently had difficulty getting detected reliably during testing, and I noticed the WavetablePi I'm trying to use on it for MIDI either would not power on, or it keeps rebooting when it does, indicating a possible power issue, so I replaced the regulators on the CT2290 (a 7805 and a 7809). After replacement the card can be reliably detected, but WavetablePi still reboots so I have to use something else... most likely the wavetable header of that card simply couldn't provide enough power for WavetablePi (which itself uses a Raspberry Pi Zero 2W).
Not sure how long the lifespan of those regulators usually are but they are probably the reason why some ISA sound cards don't get reliably detected, that were often dismissed as being not properly seated. Not all ISA cards require the use of regulators, however.
EDIT: When I said the CT2290 behaving similar to CT2950 I'm mostly referring to the differences in behavior I noticed with Wolf3D engine games. With a SB16 card, digitized sounds would occasionally cut off, but it has positional effects. With a PicoGUS in SB mode there are no positional effects (all sounds are played at the same volume), yet sounds always play correctly without cutoff.
On the other hand, it seems for my board (P8B75-M), in order to use IRQ5 the printer port has to be enabled. Disabling the printer port will result in one PIRQ line taking over IRQ5 leaving only IRQ7 usable for sound cards.