I'm playing around with an AMD 5x86@160 VLB system right now. I also have a quite nice VGA card for it (an ARK Logic ARK1000VL), so it's kind of high-end (though lacking fancy storage at the moment).
For me it's the only platform where I think it's really fun to tweak the hardware on a fairly low level — e.g., messing with BIOS settings, trying various drivers/software enhancements/OS settings. So if this is what you're after, AMD is a performance option and Cyrix might be a more interesting option because it's more exotic.
But if I take your topic name at face value, there really is no such thing as a "high-end 1995 486 build". My build, for instance, is a pure 1995 machine, but really is more of a machine for someone who couldn't afford a Pentium, and thus, tried to squeeze everything out of an outdated platform. It's like calling Tualatin 1400 a "high-end 2001 Pentium 3" or AMD K6-3+ a "high-end 2000 Socket 7". Just doesn't make sense.
Like others said, a DX4 is the closest thing to a high-end 486. It existed alongside a much more expensive Socket 4 Pentium but could still beat it in most games. So technically, DX4 is still mid-range. The last high-end 486 would really be a DX2 😀
Otherwise, I think a 486 build is defined by your choice of motherboards more than anything. Do you want VLB or PCI? Which CPUs does your board support?