I'm playing around with an AMD 5x86@160 VLB system right now. I also have a quite nice VGA card for it (an ARK Logic ARK1000VL), so it's kind of high-end (though lacking fancy storage at the moment).
For me it's the only platform where I think it's really fun to tweak the hardware on a fairly low level — e.g., messing with BIOS settings, trying various drivers/software enhancements/OS settings. So if this is what you're after, AMD is a performance option and Cyrix might be a more interesting option because it's more exotic.
But if I take your topic name at face value, there really is no such thing as a "high-end 1995 486 build". My build, for instance, is a pure 1995 machine, but really is more of a machine for someone who couldn't afford a Pentium, and thus, tried to squeeze everything out of an outdated platform. It's like calling Tualatin 1400 a "high-end 2001 Pentium 3" or AMD K6-3+ a "high-end 2000 Socket 7". Just doesn't make sense.
Like others said, a DX4 is the closest thing to a high-end 486. It existed alongside a much more expensive Socket 4 Pentium but could still beat it in most games. So technically, DX4 is still mid-range. The last high-end 486 would really be a DX2 😀
Otherwise, I think a 486 build is defined by your choice of motherboards more than anything. Do you want VLB or PCI? Which CPUs does your board support?
Pentium 166 MMX Overdrive, 32 MB RAM, Ark Logic ARK1000VL, Tekram DC-680C, Turtle Beach Tropez, Gravis Ultrasound Max
Pentium III 1000, 256 MB RAM, Matrox G400 MAX, Adaptec 19160, Yamaha YMF740B